Morbidity Among Human Immunodeficiency Virus-exposed But Uninfected, Human Immunodeficiency Virus-infected, and Human Immunodeficiency Virus-unexposed Infants in Zimbabwe Before Availability of Highly Active Antiretroviral Therapy

• DOI: 10.1097/inf.0b013e3181ecbf7e
• Publication Date: 2010-08-25T07:26:12Z
• Authors: Ai Koyanagi; Jean H. Humphrey; Robert Ntozini; Kusum Nathoo; Lawrence H. Moulton; Peter Iliff; Kuda Mutasa; Andrea Ruff; Brian Ward
• Keywords: Male; Zimbabwe; Chi-Square Distribution; Infant, Newborn; Infant; HIV Infections; Infectious Disease Transmission, Vertical; Statistics, Nonparametric; 3. Good health; Cohort Studies; Hospitalization; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Antiretroviral Therapy, Highly Active; Ambulatory Care; HIV-1; Humans; Female; Morbidity

Human immunodeficiency virus (HIV) remains a major cause of pediatric morbidity in Africa. In addition, HIV-exposed, but uninfected (HEU) infants can comprise substantial proportion all born high prevalence countries and may also be vulnerable group with special health problems.A total 14,110 were recruited within 96 hours birth between November 1996 January 2000. Rates causes sick clinic visits hospitalizations during infancy investigated according to infant HIV infection group: infected-intrauterine, infected-intrapartum, postnatally-infected, HEU, not-exposed (born HIV-negative mother).A 382 499 188 2849 9207 included the analysis. Compared infants, HIV-infected made 2.8 times more all-cause required 13.3 hospitalizations; they had 7.2 23.5 for lower respiratory tract after neonatal period 159.9 likely hospitalized malnutrition second half infancy. 1.2 common among HEU inversely associated maternal CD4 cell count, significantly higher except those whose mothers count ≥ 800 cells/μL, which was mean value women enrolled trial.Morbidity is extremely infants. increases severity disease, <800 cells/μL.