Impact of HIV Severity on Cognitive and Adaptive Functioning During Childhood and Adolescence

• DOI: 10.1097/inf.0b013e318253844b
• Publication Date: 2012-03-10T10:50:15Z
• Authors: Renee Smith; Miriam Chernoff; Paige L. Williams; Kathleen M. Malee; Patricia A. Sirois; Betsy Kammerer; Megan Wilkins; Sharon Nichols; Claude Mellins; Ann Usitalo; Patricia Garvie; Richard Rutstein
• Keywords: Adaptive functioning; Cognitive skill

The influence of disease severity on cognitive and adaptive functioning in perinatally HIV-infected youth with (PHIV+/C) without (PHIV+/NoC) a previous AIDS-defining illness (Centers for Disease Control Prevention Class C event), compared HIV-exposed but uninfected (PHEU) is not well understood.This was cross-sectional analysis PHIV+/C (n = 88), PHIV+/NoC 270) PHEU 200) aged 7-16 years, from multisite prospective cohort study. Youth caregivers completed the Wechsler Intelligence Scale Children, Fourth Edition Adaptive Behavior Assessment System, Second Edition, respectively. We means rates impairment between groups, examined associations other psychosocial factors.Overall mean scores measures were low average range all 3 groups. After adjustment covariates, full-scale intelligence quotient significantly lower group than groups (mean 77.8 versus 83.4 83.3, respectively), whereas no significant differences observed any domain. Lower performance primarily attributable to prior diagnosis encephalopathy. No functioning.For long-term survivors, HIV infection Centers event have higher risk regardless current health status; this finding appears Early preventive therapy may be critical reducing later neurodevelopmental impairments.