Selective Serotonin Reuptake Inhibiting Antidepressants Are Associated With an Increased Risk of Nonvertebral Fractures

• DOI: 10.1097/jcp.0b013e31817e0ecb
• Publication Date: 2009-03-05T19:52:39Z
• Authors: Gijsbertus Ziere; Jeanne P. Dieleman; Tischa J.M. van d...; Albert Hofman; Huibert A.P. Pols; Bruno H.Ch. Stricker
• Keywords: Serotonin Uptake Inhibitors

Background: Fractures related to osteoporosis and falling constitute a major health problem in the elderly population. Exposure antidepressants is associated with an increased risk of falls fractures, but most previous studies incriminate tricyclic (TCAs) rather than selective serotonin reuptake inhibitors (SSRIs). Objective: To examine association between antidepressants, including TCAs, SSRIs, other nonvertebral fractures elderly. Design: Prospective population-based cohort study. Setting: The Rotterdam Study, consisting 7983 individuals aged 55 years older. Participants: All persons from Study. Results: One thousand two hundred nineteen experienced fracture, 25 during TCA use 18 SSRI use. After adjustment for age, sex, lower-limb disability, depression, fracture was 2.35 (95% confidence interval, 1.32-4.18) current users SSRIs compared nonusers antidepressants. Multiple adjusting many possible factors did not affect association. deal potential confounding by indication, we subsequently restricted analysis antidepressant (n = 1217). Compared past TCAs or had 2.07-fold 1.23-3.50) which further prolonged In this analysis, depressive state at baseline follow-up play role, suggesting absence indication. that decreased Conclusions: Not only also have significantly especially after Despite fewer early adverse effects physicians treating patients should be aware unfavorable long-term consequence on risk.