Roles of Serum Clara Cell Protein 16 and Surfactant Protein-D in the Early Diagnosis and Progression of Silicosis

• DOI: 10.1097/jom.0b013e318124a927
• Publication Date: 2007-08-07T07:08:51Z
• Authors: Shi-Xin Wang; Ping Liu; Mao-Ti Wei; Lei Chen; Yang Guo; Ran-Yang Wang; Zhi-Guang Tu; Xian-Cai Liang
• Keywords: Silicosis; Pathogenesis

Objective: To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis pathogenesis silicosis. Methods: Thirty healthy volunteers, 30 silica-exposed workers, workers with suspected silicosis phase I were included. Serum CC16 SP-D concentrations determined using enzyme-linked immunosorbent assay. Results: decreased when compared controls, but levels increased, this trend was obvious 0+ groups. Discriminant analysis showed that accuracies classifying group membership into control, 0, 0+, 86.7%, 46.7%, 66.7%, 70%, respectively, total classification accuracy rate 67.5%. Conclusion: may be useful for diagnosis, concentration associate