Acute In Vivo Evaluation of an Implantable Continuous Flow Biventricular Assist System

• DOI: 10.1097/mat.0b013e31815b2d1e
• Publication Date: 2009-03-05T06:22:43Z
• Authors: Diyar Saeed; Yoshio Ootaki; Chiyo Ootaki; Masatoshi Akiyama; Tetsuya Horai; Jacquelyn Catanese; Hideyuki Fumoto; Raymond Dessoffy; Alex L. Massiello; David J. Horvath; Qun Zhou; Ji-Feng Chen; Stephen Benefit; Leonard A.R. Golding; Kiyotaka Fukamachi
• Keywords: Contractility; Left atrial pressure; Afterload

An implantable biventricular assist device offers a considerable opportunity to save the lives of patients with combined irreversible right and left ventricular failure. The purpose this study was evaluate hemodynamic physiologic performance implantation CorAide™ (LVAD) DexAide (RVAD). Acute responses were evaluated after simulating seven different physiological conditions in two calves. Evaluation performed by fixing speed one individual pump increasing other. Under all conditions, increased LVAD or RVAD resulted flow. predominant pathophysiologic effect independently varying CorAide speeds that atrial pressure very sensitive above 2,400 rpm, whereas demonstrated much less sensitivity speed. increase aortic flow observed while speed, especially under low contractility, fibrillation, high pulmonary artery pressure, circulatory blood volume conditions. In conclusion, proper RVAD-LVAD balance should be maintained avoiding overdrive. Additional studies will further investigate these pumps chronic animal models.