Anticoagulant-resistant thrombophilia in a patient with polycythemia vera

• DOI: 10.1097/mbc.0b013e32834aa7d7
• Publication Date: 2011-10-04T22:52:51Z
• Authors: Subhraleena Das; Hatim Karachiwala; Sujith V. Cherian; Amarinder S. Garcha; Sushama Jasti; Ajeet Gajra
• Keywords: Phlebotomy

Mechanical valve thrombosis is a rare condition in an adequately anticoagulated patient the absence of underlying thrombophilia. We report case 76-year-old male with mechanical prosthetic mitral as presenting feature polycythemia vera. The was treated thrombolysis at time acute presentation and subsequently maintained on low molecular weight heparin, low-dose aspirin, phlebotomy hydroxyurea. Hemoglobin, leucocytosis platelet count were controlled for almost 4 years after which suffered second, fatal episode setting therapeutic anti-Xa level. This highlights thrombotic risks associated proposed mechanisms hypercoagulability vera are reviewed. To best our knowledge, thromboses has not been reported previously.