Alterations of sympathetic nervous system, coagulation and platelet function in gestational diabetes

• DOI: 10.1097/mbc.0b013e3283540c2d
• Publication Date: 2012-05-24T15:17:46Z
• Authors: Maritta Pöyhönen-...; Lotta Joutsi-Korh...; Riitta Lassila; Risto Kaaja
• Keywords: Sympathetic nervous system

Gestational diabetes is associated with increased risk for venous thromboembolism. Activation of sympathetic nervous system affects blood coagulation, fibrinolysis and platelet activation by several mechanisms. We aimed to study the relationship system, coagulation function in gestational diabetes. Forty-one white women diabetes, 22 healthy pregnant 14 nonpregnant controls were studied. assayed serial nocturnal (at 12 p.m., 4 a.m. 7 a.m.) changes adrenergic transmitter noradrenaline, variables PFA-100. Plasma noradrenaline from both groups. During same time period, prothrombin (PT) shortened compared controls. In FVIII:C levels lower normal pregnancy also von Willebrand factor tended be lower. Platelet activity at midnight without differences between pregnancy. concomitant early morning stimulation extrinsic pathway (shortened PT). Decreased may refer compensatory anticoagulatory mechanism. These alterations could reflect pregnancy-related thromboembolism