Pulse pressure and nocturnal fall in blood pressure are predictors of vascular, cardiac and renal target organ damage in hypertensive patients (LOD-RISK study)

• DOI: 10.1097/mbp.0b013e32832e062f
• Publication Date: 2009-07-21T07:31:17Z
• Authors: Luis García-Ortiz; Manuel A. Gómez-M...; Javier Martín-Mor...; Luis J. González-...; Jose I. Recio-Rod...; Yolanda Castaño-S...; Gonzalo Grandes; Carlos Martínez-S...
• Keywords: Dipper; Pulse pressure

Objectives To analyse the relationship between various parameters derived from ambulatory blood pressure monitoring (ABPM) and vascular, cardiac renal target organ damage. Methods A cross-sectional, descriptive study. It included 353 patients with short-term or recently diagnosed hypertension. Primary measurements: ABPM, carotid intima–media thickness (IMT), Cornell voltage–duration product (Cornell VDP), glomerular filtration rate albumin/creatinine ratio to assess Results Two hundred twenty-three (63.2%) were males, aged 56.12±11.21 years. The nocturnal fall in was 11.33±8.41, a dipper pattern 49.0% (173), nondipper 30.3% (107), extreme 12.7% (45) riser 7.9% (28). IMT lower (0.716±0.096 mm) better (0.794±0.122 (P<0.05). VDP higher (1818.94±1798.63 mm/ms 140.78±366.38 mg/g, respectively) than other patterns. In multivariate analysis after adjusting for age, sex antihypertensive treatment, as dependent variable 24-h pulse (β = 0.003), rest 12.04), percentage of systolic −3.59), heart 1.83) standard deviation 5.30) remain within equation. Conclusion estimated ABPM is predictor vascular measured