Three-Combination Probiotics Therapy in Children With Salmonella and Rotavirus Gastroenteritis

• DOI: 10.1097/mcg.0b013e31828f1c6e
• Publication Date: 2013-04-30T12:50:04Z
• Authors: Yung-Feng Huang; Po-Yen Liu; Ying-Yao Chen; Bao-Ren Nong; I-Fei Huang; Kai-Sheng Hsieh; Kow-Tong Chen
• Keywords: Acute gastroenteritis; Rotavirus gastroenteritis

Goals: Quantitative Vesikari scales and qualitative severe diarrhea (Vesikari scale ≥11) assessments were used to grade the Salmonella-induced rotavirus-induced gastroenteritis severity. A significant reduction in score was evaluate efficacy of three-combination probiotics (BIO-THREE). Background: Several studies have shown that rotavirus Salmonella infections are leading causes infectious gastroenteritis. Although been effective some studies, use 3-combination formulation is rare. Study: This single-center, open-label, randomized, controlled trial included 159 patients (age range, 3 mo 14 y) hospitalized with between February 2009 October 2010. Results: Patients grouped according pathogen identified (48, Salmonella; 42, rotavirus; 69, unknown origin). The total duration significantly shorter for children who received BIO-THREE (P<0.0001). After administration, there less intervention group at day 3. or frequency results did not reveal differences groups (except 5 rotavirus), no changes other clinical parameters length hospital stay. Conclusions: Seven-day administration demonstrated high safety infants incidence reduced origin groups.