Decreased parasympathetic activity in patients with functional dyspepsia

• DOI: 10.1097/meg.0000000000000111
• Publication Date: 2014-06-04T13:19:25Z
• Authors: Kursat Dal; Onur S. Deveci; Metin Kucukazman; Naim Ata; Omer Sen; Selcuk Ozkan; Abdullah O. Yeniova; Salih Başer; Esin Beyan; Yaşar Nazligul; Bunyamin Yavuz; Derun T. Ertugrul
• Keywords: Epigastric pain

Functional dyspepsia (FD) can be described as the presence of symptoms such bothersome postprandial fullness, early satiation, epigastric pain, and burning without any evidence structural disease. The aim this study was to evaluate autonomic nervous system using heart rate variability (HRV) in patients with distress syndrome pain syndrome.The population included 64 consecutive a diagnosis FD 62 age-matched sex-matched healthy control individuals no clinical gastrointestinal, systemic, or cardiovascular diseases. All underwent upper gastrointestinal endoscopy 24 h Holter monitoring.There were 30 34 syndrome. Twenty-four hour square root mean squared differences successive normal intervals (RMSSD) (30.5 ± 12.4, 35.8 13.9; P=0.047), proportion derived by dividing number interval greater than 50 ms (PNN50) (9.8 3.9, 14.1 7.3; P=0.017), daytime PNN50 (6.8 1.6, 18.4 13.8; P<0.001), night SD (SDNN) (111.4 39.9, 133.4 29.8; P=0.001), RMSSD (31.7 38.2 17.5; P=0.019) significantly lower controls. Other HRV parameters not different between two groups. Changes these showed decreased parasympathetic tone discordance sympathovagal activity FD.Our FD. Further studies are required significance clarify mechanism