Reflux and irritable bowel syndrome are negative predictors of quality of life in coeliac disease and inflammatory bowel disease

• DOI: 10.1097/meg.0b013e328342a547
• Publication Date: 2010-12-22T05:16:04Z
• Authors: Stephen M. Barratt; John S. Leeds; Kerry Robinson; Premal J. Shah; Alan J. Lobo; Mark E. McAlindon; David S. Sanders
• Keywords: Depression

Background and aim An increased prevalence of reflux irritable bowel syndrome (IBS) symptoms is associated with coeliac disease inflammatory (IBD). We aimed to determine the IBS in a cohort patients IBD their relationship quality life (QoL) psychological distress. Methods Histologically proven (n=225), ulcerative colitis (UC) (n=228), Crohn's (CD) (n=230) age/sex-matched controls (n=348) completed Short-Form 36 (SF-36)-Item Health Survey, Hospital Anxiety Depression Scale (HADS), screen Rome II criteria. Results UC report higher SF-36 scores than disease; CD fairing worse overall (P≤0.0001). Reflux prevalence: 66%; 62%; 72%; 50%. Patients greater severity: odds ratio=6.8, 95% confidence interval=3.6–12.7, P≤0.001; ratio=2.2, interval=1.6–3.2, P≤0.0001. Stepwise reductions association increasing severity were found 22%; 16%; 24%; 6%. Concomitant was reduced Conclusion are more prevalent comparison age-matched sex-matched controls. These additional QoL likelihood anxiety depression. may be improved if assessed for IBS.