Long-Term Mesalamine Maintenance in Ulcerative Colitis

• DOI: 10.1097/mib.0b013e318280b1b8
• Publication Date: 2013-03-22T21:38:20Z
• Authors: Nabeel Khan; Ali M. Abbas; Yordanka N. Koleva; Lydia A. Bazzano
• Keywords: Adult; Aged, 80 and over; Male; Time Factors; Adolescent; Dose-Response Relationship, Drug; Anti-Inflammatory Agents, Non-Steroidal; Administration, Oral; Middle Aged; Prognosis; Medication Adherence; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Injections, Intravenous; Humans; Colitis, Ulcerative; Female; Mesalamine; Aged; Follow-Up Studies; Retrospective Studies

There are limited data about the long-term follow-up of patients with ulcerative colitis (UC) maintained on high versus low doses mesalamine. We evaluated best average daily dose that would keep disease in remission. Nationwide were obtained from Veterans Affairs health care system for period 2001 to 2011. Those who started mesalamine maintenance during this included. Average and level adherence assessed between first dispense date flare defined as filling 40 mg/day or more oral prednisone any intravenous steroids. Patients an 2.4 2.8 g/day (low dose) compared 4.4 4.8 (high dose). Adherence was using continuous single interval medication availability indicator. included 4452 a median 6 years. no significant reduction risk flares when comparing among [hazard ratio = 0.96, P 0.8)] medium (hazard 0.74, 0.17) adherence. However, there 0.28, 0.003). Our show starting patient mesalamine, is difference long have moderate