Isolated Active Ileitis

• DOI: 10.1097/mib.0b013e31828dc68b
• Publication Date: 2013-06-08T12:00:11Z
• Authors: Sarah O’Donnell; Paul L. Crotty; Maria O’Sullivan; Niall Breslin; H. J. O’Connor; Colm A. O’Morain; Barbara M. Ryan
• Keywords: Ileitis

Ileal intubation is being increasingly performed at colonoscopy and has in turn lead to an recognized subgroup of patients—those with mild terminal ileal inflammation, entity that we have coined isolated active ileitis (IAI). The aims this study were define the natural history IAI determine if shares a similar genetic serologic profile Crohn's disease (CD). Patients identified from our institution's histopathology endoscopy databases. Cases attended for repeat blood analyzed expression antineutrophil cytoplasmic antibody, anti-OmpC, anti-Saccharomyces cerevisiae antigen (ASCA) IgA, ASCA IgG, anti-CBir antibodies NOD2 genotyping. Age sex-matched healthy controls, CD, UC cases also recruited. Sixty-three patients There was no significant difference prevalence between controls OmpC, or IgG. presence all 5 significantly higher CD group than group, P < 0.05. 28.6% carried one more variants, compared 26.2% cohort 6.1% controls. Forty-three underwent follow-up ileocolonoscopy. Six 43 (14%) had definite CD. A majority developed persistent symptoms abnormalities; however, only 14% classical, histological, radiological features Although low level seropositivity, they do share excess mutations cases.