Liposomal Amphotericin B–Induced Hypotension Leading to ST Segment Elevated Myocardial Infarction

• DOI: 10.1097/mjt.0b013e3182192e70
• Publication Date: 2011-07-06T08:47:16Z
• Authors: Harsh Golwala; Nishit Patel; Soni Zacharias; Pedro Lozano
• Keywords: Male; 03 medical and health sciences; Antifungal Agents; 0302 clinical medicine; Amphotericin B; Myocardial Infarction; Humans; Hypotension; Histoplasmosis; Aged; 3. Good health

We hereby report a short case of 71-year-old gentleman who developed ST segment elevation myocardial infarction shortly after starting the infusion of liposomal amphotericin B for disseminated histoplasmosis. We also discuss the novel pathogenesis of specific liposomal component of amphotericin B that contributed to the acute cardiopulmonary compromise in our patient leading to subsequent myocardial infarction.