Intraperitoneal radioimmunotherapy to treat the early phase of peritoneal dissemination of human colon cancer cells in a murine model

• DOI: 10.1097/mnm.0b013e328013e5a8
• Publication Date: 2006-12-25T09:02:20Z
• Authors: Seigo Kinuya; Kunihiko Yokoyama; Makoto Fukuoka; Takashi Hiramatsu; Hirofumi Mori; Kazuhiro Shiba; Naoto Watanabe; Noriyuki Shuke; Takatoshi Michigishi; Norihisa Tonami
• Keywords: Peritoneal cavity; Intraperitoneal injection

Background and aim In patients with a high risk of peritoneal dissemination colon cancer, treatment adjuvant to surgical resection would improve their prognosis. We aimed determine whether radioimmunotherapy employing radiolabelled monoclonal antibody work in this situation. Methods A murine model was established female Balb/c nu/nu mice by intraperitoneal injection LS180 human cancer cells. Radioimmunotherapy 7.4 MBq IgG1, anti-colorectal A7 antibody, 131I the chloramine-T method conducted intraperitoneally on days 0, 3, 7 14 after cell inoculation, respectively. Results at any timing improved survival as compared those non-treated treated daily dose 30 mg · kg−1 5-fluorouracil for 4 consecutive days. The best improvement obtained when day 0. Conclusion These results indicate that may effectively kill cells disseminated cavity before formation tumours and, therefore, an prevent metastasis cancer.