Fluorodeoxyglucose uptake in the bone marrow after granulocyte colony-stimulating factor administration in patients with non-Hodgkin's lymphoma

• DOI: 10.1097/mnm.0b013e328346b32a
• Publication Date: 2011-04-14T07:59:55Z
• Authors: Kohei Hanaoka; Makoto Hosono; Kimio Usami; Yoichi Tatsumi; Yuzuru Yamazoe; Yoshihiro Komeya; Norio Tsuchiya; Kazunari Ishii; Mitsugu Sumita
• Keywords: Standardized uptake value

To clarify the change in fluorodeoxyglucose (FDG) uptake by bone marrow over time after administration of granulocyte colony-stimulating factor (G-CSF), we evaluated correlation between interval from last day G-CSF to positron emission tomography/computed tomography (PET/CT) study and spinal accumulation patients with non-Hodgkin's lymphoma.A total 127 confirmed lymphoma who underwent FDG PET within 60 days were retrospectively reviewed. Thirty age-matched sex-matched healthy controls also included evaluate physiological uptake. PET/CT examinations reviewed, maximum standardized value (SUVmax) was measured placing volumetric regions interest each thoracic lumbar vertebra on images referring CT images. Bone SUV defined as mean SUVmax vertebra. The plotted analyzed polynomial approximation.In controls, spine determined. In lymphoma, decreased reached a plateau at about 14 administration, this higher 5% than 10 days. declined 'physiological range', that is, mean+1 standard deviation patients, 7 days.For study, an is recommended minimize influence when evaluating treatment response lymphoma.