Diagnostic performance of cardiac fusion images from myocardial perfusion imaging and multislice computed tomography coronary angiography for assessment of hemodynamically significant coronary artery lesions

• DOI: 10.1097/mnm.0b013e32834d3bde
• Publication Date: 2011-11-01T07:45:19Z
• Authors: Toshiaki Kadokami; Shin-ichi Ando; Hidetoshi Momii; Masayoshi Yoshida; Sumito Narita; Tomohisa Fukunaga; Jun-ichiro Nishi; Akira Tamura
• Keywords: Coronary arteries

Background In detecting coronary artery disease (CAD), fusion images obtained by combining myocardial perfusion imaging (MPI) and computed tomography angiography (CTCA) have shown a higher accuracy clinical usefulness than these modalities used separately or simple comparison of individual images. However, the use has been restricted necessity obtaining with an integral type device devices made same manufacturer. Thus, we evaluated detection hemodynamically significant CAD created newly developed general-purpose application that can be any device. Methods results 49 patients, MPI during exercise at rest CTCA were combined into using new application. As reference standard, comparative interpretation conventional arteriography (CAG) was adopted. Hemodynamically diagnosed when showed reversible defect in region greater 50% luminal stenosis on CAG. The capability to detect compared alone. Fusion ability (sensitivity 80%, specificity 94%, positive predictive value 77%, negative 95%) alone (77, 77, 46, 93%, respectively; vs. CTCA: P=0.0002, P=0.0001). Conclusion superior for CAD.