Utility of 18F-FDG PET-CT in staging and restaging of patients with malignant salivary gland tumours

• DOI: 10.1097/mnm.0b013e32835bc4c4
• Publication Date: 2012-12-12T07:53:41Z
• Authors: Punit Sharma; Tarun K. Jain; Harmandeep Singh; Sudhir K.C. Suman; Nauroze A. Faizi; Rakesh Kumar; Chandrasekhar Bal; Arun Malhotra; Rakesh Kumar
• Keywords: Adult; Male; Submandibular Gland; Middle Aged; Salivary Gland Neoplasms; Multimodal Imaging; 3. Good health; Sublingual Gland; 03 medical and health sciences; 0302 clinical medicine; Fluorodeoxyglucose F18; Positron-Emission Tomography; Image Processing, Computer-Assisted; Humans; Parotid Gland; Female; Radiopharmaceuticals; Tomography, X-Ray Computed; Aged; Neoplasm Staging; Retrospective Studies; Ultrasonography

The aim of this study was to evaluate the clinical utility (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) in staging and restaging patients with malignant primary salivary gland tumours.Data pertaining 30 (age: 43.8±16.8 years; male/female: 20/10) histopathologically proven tumours who underwent 36 F-FDG PET-CTs were retrospectively analysed. Ten performed for 26 restaging. site parotid 22 patients, submandibular seven minor one patient. (18)F-FDG PET-CT images revaluated by two nuclear medicine physicians consensus. Findings grouped into local disease, nodal disease distant metastasis. Results compared those conventional imaging modalities [CIM (CT/ultrasound/bone scintigraphy)] when available (n=28). Clinical or follow-up (minimum 6 months) data along histopathological information (when available) taken as reference standard.Overall, 25 positive 11 negative disease. showed 21 17 metastasis nine (lungs, four; liver, three; bones, thyroid, one). Twenty-three true positive, negative, false negative. overall sensitivity 92%, specificity 82%, predictive value 82% accuracy 89%. No significant difference seen between groups (100 vs. 85%; P=0.468). In whom comparable CIM (n=28), did not show any advantage over (P=0.012) but more specific (71 43%).(18)F-FDG shows high tumours. It is than purpose.