Effects of Gadolinium Chloride and Glycine on Hepatic and Pancreatic Tissue Damage in Alcoholic Pancreatitis

• DOI: 10.1097/mpa.0b013e3181bd6470
• Publication Date: 2010-03-25T06:29:14Z
• Authors: Lutz Schneider; Thilo Hackert; Thomas Longerich; Werner Hartwig; Stefan Fritz; Ralf Krych; Franco Fortunato; Martha-Maria Gebhard; Jens Werner
• Keywords: Pancreatic injury; Kupffer cell

Systemic complications in alcoholic pancreatitis are supposed to be aggravated by inflammatory liver damage. Resident macrophages including hepatic Kupffer cells play a pivotal role mediating systemic severe necrotizing (SNP). The aim of this study was evaluate the effects cell inhibition on damage experimental pancreatitis.Rats were fed with either alcohol or control diet for 6 weeks before induction SNP. Animals allocated into 4 groups: healthy controls, controls SNP, SNP gadolinium chloride glycine (permanent vs temporary cells) prophylaxis. Hepatic microcirculation and morphologic pancreas assessed.Alcohol feeding increased pancreatic injury compared alone. Gadolinium improved microcirculation. In contrast, morphological reduced but not glycine.Alcohol exposure aggravates reduces both microcirculatory damage, whereas did improve histological