Octreotide Ameliorates Intestinal Dysmotility by Interstitial Cells of Cajal Protection in a Rat Acute Necrotizing Pancreatitis Model

• DOI: 10.1097/mpa.0b013e318220afab
• Publication Date: 2011-07-20T11:34:59Z
• Authors: Hui Zhou; Jun Gao; Wenbin Wu; Li Liu; Lei Wei; Duowu Zou; Zhaoshen Li
• Keywords: Necrotizing pancreatitis

Objectives: Intestinal motility is impaired in acute necrotizing pancreatitis (ANP). The aim of present study was to investigate the effects octreotide on small intestinal motor function during experimentally induced ANP. Methods: l-Omithine intraperitoneally injected induce Octreotide administrated subcutaneously every 8 hours. intestine migrating myoelectrical complexes and slow waves vivo were recorded before after (24, 48, 72 hours) ANP induction. morphological alterations interstitial cells Cajal (ICCs) deep muscular plexus evaluated by immunohistochemistry Western blots. Results: Disturbed complex cycle length decreased dominant frequency exacerbated gradually with time. bolus applications per hours attenuated these functional abnormalities. result suggested that might ameliorate damage ICCs at 48 Decreased expression c-Kit protein also octreotide. Conclusions: pathogenesis ileus may be related sustained deficiencies ICCs. severity minimizing injury Abbreviations: - pancreatitis, Cajal, MMCs complexes, DMP plexus, SAP severe SOM somatostatin, IP- intraperitoneal, GAPDH glyceraldehyde-3-phosphate dehydrogenase, IR immunoreactive