Impact of Histological Response After Neoadjuvant Chemoradiotherapy on Recurrence-Free Survival in UICC-T3 Pancreatic Adenocarcinoma But Not in UICC-T4

• DOI: 10.1097/mpa.0b013e3182236442
• Publication Date: 2011-10-04T18:18:08Z
• Authors: Yasuhiro Murata; Shugo Mizuno; Masashi Kishiwada; Takashi Hamada; Masanobu Usui; Hiroyuki Sakurai; Masami Tabata; Hiroyuki Inoue; Taizo Shiraishi; Shuji Isaji
• Keywords: Chemoradiotherapy; Neoadjuvant Therapy; Complete response

Objectives Although the prognostic benefit of neoadjuvant chemoradiotherapy (NCRT) against pancreatic cancer has been indicated by several reports, it is controversial whether histological response associated with prognosis. The objective was to explore relationship between and prognosis in T3 T4 adenocarcinoma. Methods We histologically examined resected specimens obtained from 58 patients (T3, n = 40; T4, 18) for whom we performed curative-intent resection after NCRT. Histological evaluated according Evans's criteria determine influenced survival. Results In tumors, 13 (32.5%) belonged high responders (tumor destruction >50%) (R0, 13) 27 (67.5%) low ≤50%) 22, R1, 3, R2, 2). Recurrence-free survival rate significantly higher than (3-year recurrence-free rates: 71.3% vs 13.1%, P 0.0095). however, only 1 (5.6%) a responder, R0 5 (27.8%). Conclusions considered significant indicator, securing surgical margin, whereas NCRT did not provide beneficial response, margin.