Leptin Assessment in Acute Lymphocytic Leukemia Survivors: Role of Cranial Radiotherapy?

• DOI: 10.1097/mph.0b013e318159a545
• Publication Date: 2009-03-03T23:51:54Z
• Authors: Adriana Aparecida...; Angela Maria Spin...; Patricia Debora C...; Maria Lucia de Ma...; Antonio Sergio Pe...
• Keywords: Acute lymphocytic leukemia

Leptin has been hypothesized to play a role in the development of obesity leukemia survivors, particularly those who have received cranial radiotherapy. This cross-sectional study evaluated relationship between leptin levels and body mass index (BMI) sample 26 acute lymphocytic survivors both sexes, treated with without irradiation, aged 7.6 17 years, at mean 3.4+/-2.0 years off treatment. There were significantly more males among irradiated group (P<0.001), even though no differences encountered pubertal stage (P=1.000), BMI standard deviation score (mean+/-SD) (0.68+/-1.00 vs. 1.19+/-0.78; P=0.164), or concentrations (17.01+/-17.04 23.3+/-13.4; P=0.309). Nonetheless, there was positive correlation natural logarithm [t(22)=2.348, P=0.028], however, recorded nonirradiated patients [F(2,22)=0.384, P=0.685]. When this compared significant difference [F(2,22)=4.907, P=0.017], having strongest association (R(2)males=65.5%, R(2)females=34.7%). is reliable adiposity as it strongly correlates BMI. Overall, current data suggest that irradiation did not upon relationship; sex influenced positively correlation.