A Marked Decrease in CD4-positive Lymphocytes at the Onset of Hepatitis in a Patient With Hepatitis-associated Aplastic Anemia

• DOI: 10.1097/mph.0b013e31822bf699
• Publication Date: 2013-06-13T21:27:59Z
• Authors: Takahiro Ikeda; Akira Morimoto; Sachie Nakamura; Koji Yokoyama; Tomomi Hayase; Yukiko Oh; Yoshifumi Kashii; Shigeru Yotsumoto; Hiroaki Okamoto; Mariko Y. Momoi
• Keywords: Lymphocytopenia; Aplastic anemia; Hepatitis B

A 10-year-old Japanese boy developed acute hepatitis with high levels of serum Torque teno virus DNA and marked lymphocytopenia, especially CD4+ T-lymphocytopenia. Although the total lymphocyte counts rose as patient recovered from hepatitis, this was largely because a rise in CD8+ cells. In contrast, cells poorly, resulting further striking fall CD4/8 ratio. Two months later, hepatitis-associated aplastic anemia. He successfully treated immunosuppressive therapy, which normalized subset proportions. T-cell subsets analysis at onset might be useful for predicting development