Variants of Cardiomyopathy and Hypertension in Neuroblastoma

• DOI: 10.1097/mph.0b013e318290c628
• Publication Date: 2013-05-04T13:40:24Z
• Authors: Sit Yee Kwok; Frankie Wai Tsoi ...; Amy Fung Cheung Lo; Wing Kwan Leung; Man Ching Yam; Chi Kong Li
• Keywords: Cardiomyopathy, Dilated; Heart Failure; Infant; Blood Pressure; Cardiomyopathy, Hypertrophic; Prognosis; 3. Good health; Neuroblastoma; 03 medical and health sciences; Catecholamines; 0302 clinical medicine; Echocardiography; Child, Preschool; Hypertension; Humans; Female

Catecholamine-associated cardiomyopathies caused by neuroblastoma have rarely been reported. We are reporting 2 cases of neuroblastoma associated with hypertension and severe cardiomyopathic changes in different extremes. One case was dilated cardiomyopathy with heart failure, and the other showed echocardiographic features simulating hypertrophic obstructive cardiomyopathy. Both girls had high levels of urine catecholamines on presentation. Anthracycline group of chemotherapy was avoided. Chemotherapy and tumor resection resulted in successful normalization of blood pressure and regression of cardiomyopathic changes. Blood pressure and cardiomyopathic changes should be monitored not only at presentation, but also during the treatment for neuroblastoma.