Steatohepatitic Hepatocellular Carcinoma (SH-HCC)

• DOI: 10.1097/pas.0b013e3181f31caa
• Publication Date: 2010-10-22T02:02:05Z
• Authors: Marcela Salomao; Woojin M. Yu; Robert S. Brown; Jean C. Emond; Jay H. Lefkowitch
• Keywords: Steatosis; Steatohepatitis; Hepatitis C

In explant livers with chronic hepatitis C (HCV-C) we have noted a distinctive histologic variant that termed steatohepatitic hepatocellular carcinoma (SH-HCC) features resembling non-neoplastic steatohepatitis, including large droplet steatosis, ballooning of malignant hepatocytes, Mallory-Denk bodies, inflammation, and pericellular fibrosis. This study was undertaken to further describe the characteristics prevalence this in HCV-C any possible association underlying risk factors for nonalcoholic fatty liver disease (NAFLD) steatohepatitis (NASH). We selected two 2-year periods (mid-2003 mid-2005 2007 2008), from which HCC were examined determine frequency SH-HCC. The cirrhotic also reassessed steatosis evidence steatohepatitis. Clinical records consulted concomitant NAFLD NASH factors. SH-HCC found total 22 62 cases (35.5%). Fourteen patients (63.6%) had at least one known factor NAFLD/NASH diabetes (6 22, 27.3%), obesity hypertension (11 50%), hyperlipidemia (5 27.8%). 14 SH-HCC, showed changes superimposed on otherwise typical HCV-C. conclusion, our series explants, approximately one-third HCCs show histological Underlying identified 63.6% cases. Moreover, tissue explants These results suggest pathway leading setting requires investigation future.