Immunohistochemical Assessment of Lymphovascular Invasion in Stage I Colorectal Carcinoma

• DOI: 10.1097/pas.0b013e31822d3008
• Publication Date: 2011-10-11T07:42:24Z
• Authors: Valeria Barresi; Luca Reggiani Bon...; Enrica Vitarelli; Carmela Di Gregorio; Maurizio Ponz de ...; Gaetano Barresi
• Keywords: Lymphovascular invasion; Lymphatic vessel; Occult

Several studies have suggested that the presence of occult nodal metastases (micrometastases) is related to adverse clinical course in stage I colorectal carcinoma. Herein we analyzed correlation between micrometastases and lymphovascular invasion (LVI) or lymphatic vessel density (LVD) a series carcinomas; cohort included cases characterized not by disease progression during follow-up. In these cases, LVI LVD were evidenced through immunohistochemical detection specific marker for vessels, D2-40. was significantly more frequent carcinomas (P<0.0001), high peritumoral (P<0.0001). The analysis risk indicated significant, negative, independent prognostic parameters associated with shorter disease-free survival cancer (P=0.0001; P=0.0242). conclusion, this study demonstrated first time light its independent, value neoplasia, may represent faster cheaper tool compared time-consuming evaluation select high-risk patients who benefit from adjuvant systemic treatment. Furthermore, assessment be applied establish likelihood involvement treated conservative local excision techniques, which provide no regional nodes histologic examination.