Histopathologic and Ultrastructural Features and Claudin Expression in Papillary Tumors of the Pineal Region

• DOI: 10.1097/pas.0b013e31824b7114
• Publication Date: 2012-05-15T10:46:20Z
• Authors: Michelle Fèvre Mo...; Alexandre Vasiljevic; Anne-Marie Bergem...; Michèle Bernier; Jacques Champier; Fabrice Chrétien; Dominique Figarel...; Jean-Louis Kemeny; Emmanuèle Lechapt...; Sophie Michalak; Catherine Miquel; Karima Mokthari; Isabelle Pommepuy; Isabelle Quintin ...; Audrey Rousseau; Ghislaine Saint-P...; Caroline Salon; Emmanuelle Uro-Coste; Pascale Varlet; Ingrid Kratzer; Jean-François Ghe...; Anne Jouvet
• Keywords: Claudin; Papillary tumor; Subcommissural organ; Neuroepithelial cell; Pinealoma; Ependymal Cell

Neuroepithelial papillary tumor of the pineal region (PTPR) has been defined as a distinct entity that is increasingly being recognized, with 96 cases now reported. This shares morphologic features both ependymomas and choroid plexus tumors. PTPR characterized by an epithelial-like growth pattern in which vessels are covered layers cells forming perivascular pseudorosettes. These tumors exhibit various combinations solid architecture, making differential diagnosis difficult to establish. We report detailed description histopathologic large series PTPRs from 20 different centers distinguish 2 subgroups either striking or pattern. highlight findings have unusual multiple lumina frequently show detachment border tumoral vascular wall. The present similar clinical characteristics immunophenotypes. confirmed extended results previous ultrastructural studies on presence intercellular junctions at apical part cells. expression tight junction proteins claudin-1, claudin-2, claudin-3 was investigated immunohistochemistry. Claudin-1 claudin-3, but not were expressed fetal subcommissural organ, potentially origin this tumor. In contrast, all 3 claudins papillomas. Claudin may help can be used combination other markers, such CK18, NCAM, E-cadherin, MAP-2, Kir 7.1.