Importance of NOD2/CARD15 gene variants for susceptibility to and outcome of sepsis in Turkish children*

• DOI: 10.1097/pcc.0b013e3182191c2e
• Publication Date: 2011-04-01T09:48:54Z
• Authors: Deniz Tekin; Nazan Dalgic; Zeliha Kayaalti; Tulin Soylemezoglu; Betul Diler; Busra Isin Kutlubay
• Keywords: Male; 0301 basic medicine; Polymorphism, Genetic; Turkey; Nod2 Signaling Adaptor Protein; Infant; Prognosis; 3. Good health; 03 medical and health sciences; Case-Control Studies; Child, Preschool; Sepsis; Humans; Female; Genetic Predisposition to Disease; Child

Objective: Severe sepsis remains a leading cause of morbidity and mortality in children. Given the link to pathogenesis, polymorphisms genes involved infection inflammation may influence outcomes patients with septic shock. The role mutations within innate immunity receptor NOD2/CARD15 has recently been demonstrated as risk factor for bacteremia adult sepsis. aim this study was evaluate gene pediatric Design: Prospective cohort study. Setting: A tertiary care, ten-bed, intensive care unit. Patients: One hundred twenty-eight admitted unit healthy control group were included. Interventions: Venous blood from children controls collected investigate common (Arg702Trp, Gly908Arg, Leu1007fsincC) gene. Standard polymerase chain reaction restriction fragment length polymorphism technique used determine polymorphism. Measurement Main Results: R702W, G908R, Leu1007fsinsC variants determined significant factors associated susceptibility (p = .025, p .031, .014, respectively). Sepsis-related increased carrying variant .041). Conclusions: present article is first report clinical implications Our findings suggest that play major outcome