Safety, efficacy, and tolerability of early initiation of noninvasive positive pressure ventilation in pediatric patients admitted with status asthmaticus

• DOI: 10.1097/pcc.0b013e318238b07a
• Publication Date: 2011-11-04T10:01:49Z
• Authors: Sangita Basnet; Gurpreet Mander; Jennifer Andoh; Helen Klaska; Steven Verhulst; Janak Koirala
• Keywords: Tolerability; Positive pressure ventilation

Objectives: Although noninvasive positive pressure ventilation is increasingly used for respiratory distress, there not much data supporting its use in children with status asthmaticus. The objective of this study was to determine safety, tolerability, and efficacy early initiation addition standard care the management admitted Study Design: A prospective, randomized, controlled, clinical trial. Patients: Twenty patients (1–18 yrs old) pediatric intensive unit Methods Main Results: Children were randomized receive either plus (noninvasive group) or alone (standard group). Improvement asthma score significantly greater group compared at 2 hrs, 4–8 12–16 24 hrs after interventions (p < .01). significant decrease rate ≥24 oxygen requirement noted as = .01 p .03, respectively). statistically significant, fewer required adjunct therapy (11% vs. 50%; .07). There no major adverse events related ventilation. Nine out ten tolerated through duration study; had be discontinued one patient because persistent cough. Conclusions: Early ventilation, along short acting β-agonists systemic steroids, can safe, well-tolerated, effective