Low-Dose Propranolol Improves Cutaneous Wound Healing of Burn-Injured Rats

• DOI: 10.1097/prs.0b013e31818cbf67
• Publication Date: 2008-11-19T08:15:52Z
• Authors: Bruna Romana-Souza; Adriana P. Nascim...; Andréa Monte-Alto...
• Keywords: Sirius Red; Myofibroblast

Severe burns stimulate a hypermetabolic response that causes systemic complications. Propranolol, nonselective beta-blocker, reduces this and increases survival. Nevertheless, few studies have shown the effects of propranolol on healing severe burns. This study evaluated macroscopically microscopically administration (low-dose) cutaneous wound burn-injured rats.A third-degree burn (10 percent total body surface area) was created in female Wistar rats. Beginning 1 week after burning, animals were treated daily with (n = 5) (6 mg/kg) dissolved water until they euthanized, whereas rats control group received only water. Wound area measured weekly euthanized 63 days burning. Lesions adjacent skin fixed formalin embedded paraffin. Sections stained hematoxylin eosin, Sirius red, toluidine blue, immunostained for CD68, alpha-smooth muscle actin, proliferating cell nuclear antigen.The greater than propranolol-treated 21, 53, All presented more 70 reepithelialized did not. The number inflammatory cells blood vessel density Cellular proliferation, myofibroblast density, collagen deposition, active matrix metalloproteinase-2 levels reduced compared burning.Administration improves burned rats, reducing local improving subsequent phases.