Traumatic Superior Orbital Fissure Syndrome: Assessment of Cranial Nerve Recovery in 33 Cases

• DOI: 10.1097/prs.0b013e3181dab658
• Publication Date: 2010-06-11T15:29:27Z
• Authors: Chien-Tzung Chen; Theresa Y. Wang; Pei-Kwei Tsay; Faye Huang; Jui-Pin Lai; Yu-Ray Chen
• Keywords: Adult; Male; Adolescent; Skull Fractures; Nerve Compression Syndromes; Cranial Nerves; Recovery of Function; Middle Aged; Decompression, Surgical; Facial Bones; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Fracture Fixation; Humans; Female; Child; Tomography, X-Ray Computed; Glucocorticoids; Cranial Nerve Injuries; Follow-Up Studies; Retrospective Studies

Superior orbital fissure syndrome is a rare complication that occurs in association with craniofacial trauma. The characteristics of superior orbital fissure syndrome are attributable to a constellation of cranial nerve III, IV, and VI palsies. This is the largest series describing traumatic superior orbital fissure syndrome that assesses the recovery of individual cranial nerve function after treatment.In a review from 1988 to 2002, 33 patients with superior orbital fissure syndrome were identified from 11,284 patients (0.3 percent) with skull and facial fractures. Severity of cranial nerve injury and functional recovery were evaluated by extraocular muscle movement. Patients were evaluated on average 6 days after initial injury, and average follow-up was 11.8 months.There were 23 male patients. The average age was 31 years. The major mechanism of injury was motorcycle accident (67 percent). Twenty-two received conservative treatment, five were treated with steroids, and six patients underwent surgical decompression of the superior orbital fissure. After initial injury, cranial nerve VI suffered the most damage, whereas cranial nerve IV sustained the least. In the first 3 months, recovery was greatest in cranial nerve VI. At 9 months, function was lowest in cranial nerve VI and highest in cranial nerve IV. Eight patients (24 percent) had complete recovery of all cranial nerves. Functional recovery of all cranial nerves reached a plateau at 6 months after trauma.Cranial nerve IV suffered the least injury, whereas cranial nerve VI experienced the most neurologic deficits. Cranial nerve palsies improved to their final recovery endpoints by 6 months. Surgical decompression is considered when there is evidence of bony compression of the superior orbital fissure.