The Role of Different Methods of Nerve Ablation in Prevention of Neuroma

• DOI: 10.1097/prs.0b013e3182879ec2
• Publication Date: 2013-04-30T12:34:19Z
• Authors: Harvey Chim; Erin Miller; Christy Gliniak; Mark L. Cohen; Bahman Guyuron
• Keywords: Neuroma; Sural nerve

Background: The aim of this study was to compare the incidence neuroma formation and neuropathic pain following different techniques nerve ablation in a rat sural model. Methods: Rat subjected four with standardized creation 1-cm gap (n = 15 each group). These included avulsion, transection burying muscle, folding nerve, alone. Animals were killed after 3 months. Explanted nerves sectioned stained Masson trichrome S-100 stain against neural tissue. maximal cross-sectional area neural-to-connective tissue ratio quantified. Quantitative reverse-transcriptase polymerase chain reaction 5) used analyze relative mRNA expression ciliary neurotrophic factor calcitonin gene-related peptide. Results: Neural statistically increased (p < 0.05) compared controls folded, muscle buried, transected specimens but decreased avulsed specimens. group. Relative lowest buried (4 percent control) (15 higher folded (52 (75 control). peptide highest (302 0.05). Conclusions: Folding lead histologic evidence formation, whereas leads pain, assayed by expression. Avulsion are preferable for inhibit regeneration, evidenced offers an alternative when there is no vicinity bury nerve.