Anxiety, Depression, and Cause-Specific Mortality: The HUNT Study

• DOI: 10.1097/psy.0b013e31803cb862
• Publication Date: 2007-05-01T01:05:09Z
• Authors: Arnstein Mykletun; Ottar Bjerkeset; Michael Dewey; Martin Prince; Simon Overland; Robert Stewart
• Keywords: Depression

Objective: To investigate empirically the association between anxiety/depression and cause-specific mortality with particular attention to underlying mechanisms causes of death. Depression reportedly increases general mortality. For mortality, there is evidence depression has an effect on cardiovascular disease (CVD) suicide. Less information known as other diagnoses. There scarce conflicting literature anxiety in relation Methods: Employing a historical cohort design, we used link epidemiological study comprehensive national database. We gathered baseline physical mental health (Hospital Anxiety Scale, HADS) from population-based (n = 61,349). Causes death were registered International Classification Diagnoses, 10th edition (ICD-10) during mean follow-up 4.4 years. Results: Case-level increased rate for all major disease-related death, whereas case-level comorbid did not. The was similar cardiac compared combined, confounding effects also very similar. Symptom load associated negatively both CVD cause fully adjusted models. Accidents suicide primarily anxiety/depression. Conclusions: risk factor death; it not limited or Because comparable combined mediating factors markedly similar, future investigation should be BMI body mass index; CAGE screening instrument alcohol problems; disease; HADS Hospital Scale (A D subscales); ICD-8/9/10 8th/9th/10th edition; OR odds ratio; HUNT Health Study Nord-Trøndelag County, Norway.