The effect of intensification with raltegravir on the HIV-1 reservoir of latently infected memory CD4 T cells in suppressed patients

• DOI: 10.1097/qad.0b013e3283584521
• Publication Date: 2012-09-20T07:47:58Z
• Authors: Alejandro Vallejo; Carolina Gutierrez; Beatriz Hernandez...; Laura Diaz; Nadia Madrid; María Abad-Fernandez; Fernando Dronda; María J. Perez-Elias; Javier Zamora; Eduardo Muñoz; María A. Muñoz-Fe...; Santiago Moreno
• Keywords: Raltegravir; Viremia; Memory T cell; Memory cell; Homing (biology)

Objectives: The stability of the reservoir latently infected memory CD4+ T-cells may be associated with continuous replenishment from residual HIV-1, not completely eliminated by otherwise successful antiretroviral therapy (ART). Treatment intensification could help to control virus and modify latent reservoir. objective this work is assess effect intensifying raltegravir on HIV-1 cell Design: A pilot open-label phase-II clinical trial was performed analyze ART after 48 weeks in chronically HIV-1-infected patients stable ART. Methods: We measured number T cells, viremia, 2-long terminal repeat circles, CD4+/CD8+ T-cell activation, lymphocyte subpopulations, gut homing receptor, bacterial translocation. Results: significant decay observed nine included (P = 0.021). No variation found either viremia or whereas CD8+ activation decreased at week 36 0.028). differences were naive effector counts, frequencies receptor activated cells. Bacterial translocation stable, exception a late decrease lipopolysaccharide levels. Conclusions: In noncomparative trial, treatment significantly cellular activation. Despite limitations inherent design, our results suggest that should considered as an adjuvant strategy eradicate infection.