Undiagnosed Tuberculosis Among HIV Clinic Attendees

• DOI: 10.1097/qai.0b013e318251ae0b
• Publication Date: 2012-03-07T00:49:24Z
• Authors: Tendesayi Kufa; Victor Mngomezulu; Salome Charalambous; Yasmeen Hanifa; Katherine Fielding; Alison D. Grant; Nikolas Wada; Richard E. Chaisson; Gavin J. Churchyard; Celine R. Gounder
• Keywords: Interquartile range

Initiation of antiretroviral therapy (ART) and the 3I's are strategies to prevent HIV-associated tuberculosis (TB). We describe factors associated with undiagnosed TB among HIV-infected patients attending an HIV clinic in South Africa discuss implications for 3 Is.Convenience sample attendees.HIV-infected participants were assessed using a symptom screen, sputum-smear microscopy, sputum blood mycobacterial culture, fine needle aspiration enlarged lymph nodes, chest radiography.Four hundred twenty-two enrolled. The median age CD4+ T-cell count 37 years [interquartile range (IQR): 31-44 years] 215 cells per microliter (IQR: 107-347 cells/μL). Forty-seven percent had been on ART duration 8 months 3.3-22.8 months). Three sixty-one (85.6%) reported symptoms. Twenty-seven (6.4%) met criteria bacteriologically confirmed 50 (11.6%) any form TB. Bacteriologically was counts ≤100 (odds ratio: 5.05, 95% confidence interval: 1.69 15.12) when compared >200 hemoglobin {hemoglobin < 10 g/dL [odds ratio 3.12 (95% 1.26 7.72)]}.Undiagnosed ambulatory low regardless status. screening algorithms which include testing may be effective way identify attendees at highest risk Isoniazid preventive infection control essential reducing occurrence even after initiation.