Protein Binding of Lopinavir and Ritonavir During 4 Phases of Pregnancy

• DOI: 10.1097/qai.0b013e31827fd47e
• Publication Date: 2012-12-07T11:56:44Z
• Authors: Kristine B. Patte...; Julie B. Dumond; Heather A. Prince; Amanda J. Jenkins; Kimberly K. Scarsi; Ruili Wang; Stephanie Malone; Michael G. Hudgens; Angela D. M. Kashuba
• Keywords: Adult; Ritonavir; Adolescent; HIV Infections; Blood Proteins; HIV Protease Inhibitors; Lopinavir; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Humans; Female; Pregnancy Trimesters; Prospective Studies; Pregnancy Complications, Infectious; Protein Binding

To investigate the intraindividual pharmacokinetics of total (protein bound + unbound) and unbound lopinavir/ritonavir (LPV/RTV) and to assess whether the pediatric formulation (100mg/25mg) can overcome any pregnancy-associated changes.