Accuracy of Fluorodeoxyglucose-Positron Emission Tomography for Diagnosis of Single Bone Metastasis

• DOI: 10.1097/rct.0b013e318031cc4d
• Publication Date: 2009-03-04T23:28:19Z
• Authors: Jin Hur; Choon-Sik Yoon; Young Hoon Ryu; Mi Jin Yun; Jin-Suck Suh
• Keywords: Standardized uptake value; Fluorodeoxyglucose; McNemar's test

Purpose: The aim of this study was to compare the accuracy fluorodeoxyglucose-positron emission tomography (FDG-PET) with bone scan for diagnosis single metastasis using a semiquantitative method. Material and Methods: Seventy-six patients suspected metastasis, who underwent both FDG-PET scan, were selected. number location lesions detected upon recorded, compared McNemar test. For analysis, maximum (max) standard uptake value (SUV) 2.5 used as positive cutoff metastasis. difference in max SUV among 3 groups (osteolytic, osteoblastic, benign lesions) assessed Student-Newman-Keuls Biopsy results, other imaging findings (multirow detector computed tomography, magnetic resonance imaging), patient's clinical course references. Results: There 47 metastases 29 lesions. sensitivity, specificity, scans diagnosing 89%, 41%, 71%, respectively, those 85%, 52%, 72%, respectively. These data not significantly different (P > 0.05). Using specificity FDG-PET, 83% each, improved. When classifying osteoblastic or osteolytic, higher osteolytic than = 0.001). Conclusions: Fluorodeoxyglucose-positron parameter improves diagnostic ability differentiate between