In Vivo Biochemical 7.0 Tesla Magnetic Resonance

• DOI: 10.1097/rli.0b013e31817e9122
• Publication Date: 2008-08-15T07:07:18Z
• Authors: Goetz H. Welsch; Tallal C. Mamisch; Timothy Hughes; Christoph Zilkens; Sebastian Quirbach; Klaus Scheffler; Oliver Kraff; Mark E. Schweitzer; Pavol Szomolanyi; Siegfried Trattnig
• Keywords: Flip angle; Gradient echo; Hyaline cartilage; Knee cartilage

Ultra-high-field whole-body systems (7.0 T) have a high potential for future human in vivo magnetic resonance imaging (MRI). In musculoskeletal MRI, biochemical of articular cartilage may benefit, particular. Delayed gadolinium-enhanced MRI (dGEMRIC) and T2 mapping shown at 3.0 T. Although dGEMRIC, allows the determination glycosaminoglycan content cartilage, is promising tool evaluation water collagen content. addition, zonal variation, based on tissue anisotropy, provides an indicator nature ie, hyaline or hyaline-like cartilage.Thus, aim our study was to show feasibility T2* relaxation measurements, 7.0 T MRI; evaluate measurements initial patient after matrix-associated autologous chondrocyte transplantation (MACT) knee.MRI performed MR scanner using dedicated circular polarization knee coil. The protocol consisted inversion recovery sequence multiecho spin-echo standard mapping, gradient-echo morphologic PD SPACE sequence. Twelve healthy volunteers (mean age, 26.7 +/- 3.4 years) 4 patients 38.0 14.0 were enrolled 29.5 15.1 months MACT. For 5 32.4 11.2 included. T1 maps calculated nonlinear, 2-parameter, least squares fit analysis. Using region-of-interest analysis, mean rate determined as (0) precontrast (Gd) postcontrast gadopentate dimeglumine [Gd-DTPA(2-)] measurements. obtained pixelwise, monoexponential, non-negative analysis; analysis carried out deep superficial aspects. Statistical by analyses variance.Mean values showed slightly different results femoral [T1 (0): 1259 277 ms; (Gd): 683 141 ms] compared with tibial 1093 281 769 150 ms]. Global comparable (T2: 56.3 15.2 T2*: 19.7 6.4 ms) patellar 54.6 13.0 19.6 5.2 but lower 43.6 8.5 16.6 5.6 ms). All sites significant increase from (P < 0.001). Within MACT patients, adequate could be found (56.6 13.2 (18.6 5.3 ms), which also stratification. repair tissue, global no difference, 55.9 4.9 ms 16.2 6.3 T2*. However, assessment only slight not P = 0.174; 0.150).In dGEMRIC reparative seems possible MRI. T2*, variation evaluated This aspects shows differentiation affected cartilage. studies, optimized selection, sophisticated coil technology, together increased signal ultra-high-field lead advanced imaging.