Quantification of Perfusion and Permeability in Multiple Sclerosis

• DOI: 10.1097/rli.0b013e31823bfc97
• Publication Date: 2012-02-28T10:59:35Z
• Authors: Michael Ingrisch; Steven Sourbron; Dominik Morhard; Birgit Ertl-Wagner; Tania Kümpfel; Reinhard Hohlfeld; Maximilian Reiser; Christian Glaser
• Keywords: Cerebral blood volume

The quantification of cerebral blood flow (CBF), volume (CBV), and blood-brain barrier permeability in scattered lesions the brain is a methodological challenge. We aimed to investigate feasibility 3D T1-weighted dynamic contrast-enhanced (DCE) MRI acquisition combination with 2-compartment modeling approach for CBF, CBV surface area product (PS) lesions, normal-appearing white matter (NAWM) patients multiple sclerosis (MS).In all, 19 MS (mean age 35 years, 12 female) underwent DCE-MRI spoiled gradient-echo sequence on 3T scanner. A total 44 slices (thickness 3 mm) an in-plane resolution 1.7 × mm(2) (matrix size 128 104), providing coverage whole brain, were acquired every 2.1 seconds over measurement time 420 s. Data postprocessing was performed using set models automated model selection; CBV, PS as measure leakage determined contrast-enhancing (CE) nonenhancing well NAWM.Perfusion produced reasonable values NAWM. In CE CBF (22.9 (22.7) vs. 15.8 (6.7) mL/100 mL/min), (1.18 (0.48) 0.76 (0.19) mL), (0.98 (0.46) 0.04 (0.03) mL/min) significantly (P < 0.001) higher than weakly 0.05) increased 1.00 (0.35) mL, compared NAWM, observed.Our study demonstrates quantitative assessment NAWM throughout even without previous knowledge their location. Quantification region level both but parameter maps would benefit from increase contrast-to-noise ratio. may reflect inflammatory activity, heterogeneity estimates suggests potential lesion characterization. appears hypoperfused, this accordance studies, requires validation control group.