Pulmonary Artery Relative Area Change Detects Mild Elevations in Pulmonary Vascular Resistance and Predicts Adverse Outcome in Pulmonary Hypertension

• DOI: 10.1097/rli.0b013e31826c4341
• Publication Date: 2012-08-22T11:13:48Z
• Authors: Andrew J. Swift; Smitha Rajaram; Robin Condliffe; Dave Capener; Judith Hurdman; Charlie Elliot; David G. Kiely; Jim M. Wild
• Keywords: Male; Cardiac Catheterization; Hypertension, Pulmonary; Kaplan-Meier Estimate; Middle Aged; Pulmonary Artery; Prognosis; Magnetic Resonance Imaging; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Confidence Intervals; Health Status Indicators; Humans; Female; Vascular Resistance; Aged; Retrospective Studies

The aim of this study was to evaluate the clinical use magnetic resonance imaging measurements related pulmonary artery stiffness in evaluation hypertension (PH).A total 134 patients with suspected PH underwent right heart catheterization (RHC) and on a 1.5-T scanner within 2 days. Phase contrast at trunk cine cardiac views were acquired. Pulmonary area change (AC), relative AC (RAC), compliance (AC/pulse pressure from RHC), distensibility (RAC/pulse ventricular functional indices, mass all derived. Regression curve fitting identified statistical model best fit between RHC indices. diagnostic accuracy prognostic value noninvasive RAC also assessed.The relationship vascular resistance reflected by an inverse linear model. Patients mild elevation (<4 Woods units) demonstrated reduced (P = 0.02) increased index < 0.0001) without significant loss function 0.17). At follow-up 0 40 months, 18 had died (16%). Analysis Kaplan-Meier plots showed that both predicted mortality (log-rank test, P 0.046 0.012, respectively). Area predictors using univariate Cox proportional hazards regression analysis 0.03, respectively).Noninvasive assessment is marker sensitive early predictor adverse outcome.