Quantitative Evaluation of Computed High b Value Diffusion-Weighted Magnetic Resonance Imaging of the Prostate

• DOI: 10.1097/rli.0b013e31829705bb
• Publication Date: 2013-08-01T12:28:47Z
• Authors: Marnix C. Maas; Jurgen J. Fütterer; Tom W.J. Scheenen
• Keywords: Value (mathematics)

Computed diffusion-weighted magnetic resonance imaging (cDWI) refers to the synthesizing of arbitrary b value images (DWI) from a set measured by voxelwise fitting. The objectives this study were quantitatively analyze noise and contrast-to-noise ratio (CNR) in cDWI as function numerical simulations measurements patients with prostate cancer compare directly DWI at 1400 s/mm2.Numerical performed assess image CNR both regular DWI. Forty-two (age, 51-73 years; specific antigen level, 0.5-30 ng/mL; biopsy Gleason score, 6-9) received 2 examinations 3.0 T (one values 100, 500, s/mm2 another 0, 400, 800 s/mm2) create values, without incorporating 0 their calculation. Regions interest drawn scan time adjusted (CNR eff) between = on tumor-suspicious lesions normal-appearing regions.In simulations, depended strongly value, diffusion coefficient, signal intensity but not simulated tumor normal regions showed continuous increase increasing value. Both these findings also observed vivo data. In similar eff tissue (P 0.395).The is comparable even higher calculated s/mm2, yields than DWI, which may be clinical aid management cancer.