Thallium-201 Scintigraphy Is an Effective Diagnostic Modality to Distinguish Malignant From Benign Soft-Tissue Tumors

• DOI: 10.1097/rlu.0b013e3182177407
• Publication Date: 2011-10-05T07:13:36Z
• Authors: Naoaki Kawakami; Toshiyuki Kunisada; Shuhei Sato; Yuki Morimoto; Masato Tanaka; Tsuyoshi Sasaki; Shinsuke Sugihara; Hiroyuki Yanai; Susumu Kanazawa; Toshifumi Ozaki
• Keywords: Thallium; Pigmented Villonodular Synovitis

The aim of this study is to evaluate whether thallium-201 (201-Tl) scintigraphy can differentiate malignant from benign soft-tissue tumors.Between April 1995 and December 2005, 192 patients with tumors (85 107 benign) underwent 201-Tl before treatment. Isotope uptake was used as a proxy for tumor-to-background ratio (TBR). accuracy TBR on early delayed imaging evaluated using the Mann-Whitney U χ(2) tests.There statistically significant difference in mean (124% ± 109% vs. 22% 42%, 82% 83% 12% 25%, P < 0.0001). A cutoff 20% indicated probability malignancy (82% sensitivity 77% specificity; 84% specificity, Well-differentiated liposarcomas showed low isotope accumulation, while pigmented villonodular synovitis giant cell tendon sheath high accumulation.Thallium-201 distinguish relatively accuracy. With exception grade locally aggressive tumors, may be an effective diagnostic modality tumors.