Predictive Value of Preablation Stimulated Thyroglobulin and Thyroglobulin/Thyroid-Stimulating Hormone Ratio in Differentiated Thyroid Cancer

• DOI: 10.1097/rlu.0b013e3182291c65
• Publication Date: 2011-11-05T10:56:38Z
• Authors: Yansong Lin; Tianjun Li; Jun Liang; Xiaoyi Li; Liheng Qiu; Shasha Wang; Yonghui Chen; Zengshou Kang; Fang Li
• Keywords: Thyroglobulin; Thyroid-stimulating hormone

Recent studies have shown that thyroglobulin (Tg) concentration is a useful tumor marker in follow-up of differentiated thyroid cancer (DTC) patients after thyroidectomy and subsequent radioiodine (I-131) therapy. However, its role controversial total or near-total before the first I-131 ablative treatment. So, we used thyroid-stimulating hormone (TSH) levels to normalize predictive values Tg for DTC.The study was retrospective analysis. A 244 with DTC who had undergone therapy were included. Exclusion criteria high serum antibody (TgAb) whom it not measured. Patients divided into 2 groups as M1 M0, according whether patient present without distant metastases.Preablative stimulated group M0 ranged between 0.1 348.9 ng/mL 0.2 1000 ng/mL. Tg/TSH ratios 0.000667 12.143 ng/IU 0.002948 12500 ng/IU. Both significantly different (the Wilcoxon rank sum test: P < 0.0001 [z = 8.785]; 8.850]). The areas under receiver operating characteristic curves concentrations 0.913 0.916, respectively.Both might be considered markers metastases just