Intraoperative Hand-Held Imaging γ-Camera for Sentinel Node Detection in Patients With Breast Cancer

• DOI: 10.1097/rlu.0b013e31827a278d
• Publication Date: 2013-01-26T08:22:41Z
• Authors: Sotirios Chondrog...; Alice Ferretti; Enzo Facci; Maria Cristina Ma...; Lucia Rampin; Sara Tadayyon; Margherita Maffione; Domenico Reale; Roberto Mencarelli; Adriano Marcolongo; Domenico Rubello
• Keywords: Gamma camera; Gamma probe

This study aimed to assess the feasibility and potential usefulness of a new intraoperative portable high-resolution imaging γ-camera for localization sentinel lymph node in patients with breast cancer.Sixteen T1 T2 cancer female were evaluated (mean age, 62 years) preoperative lymphoscintigraphy, acquired 30 minutes after intradermal injection 60 70 MBq (1.6-1.9 mCi) (99m)Tc-nanocolloids saline volumes 0.1 0.2 mL. Surgery took place day (18-20 hours tracer injection). For localization, traditional γ-probe was used by surgeon. Moreover, nuclear physician who present operating room.The showed very high spatial resolution (2.4 mm) 4.4 × cm(2) FOV, good sensitivity 180 cps/MBq at Plexiglas depth 1 cm. In 11 patients, γ-probe, depicted same number radioactive nodes (17 nodes; 5 which metastatic detected 6 different patients). more than lymphoscintigraphy (in total, more), one (the only that patient).Our preliminary results hand-held is feasible, not time-consuming, noninvasive procedure offering extra confidence our hands, it useful auxiliary tool especially identification located deep axilla, are difficult detect lymphoscintigraphy. Additional multicenter studies involving greater necessary confirm these promising data.