Benefits of Point-Spread Function and Time of Flight for PET/CT Image Quality in Relation to the Body Mass Index and Injected Dose

• DOI: 10.1097/rlu.0b013e31828da3bd
• Publication Date: 2013-04-18T12:43:09Z
• Authors: Go Akamatsu; Katsuhiko Mitsumoto; Kaori Ishikawa; Takafumi Taniguchi; Nobuyoshi Ohya; Shingo Baba; Koichiro Abe; Masayuki Sasaki
• Keywords: Adult; Aged, 80 and over; Male; 2. Zero hunger; Time Factors; Phantoms, Imaging; Dose-Response Relationship, Radiation; Middle Aged; Multimodal Imaging; Body Mass Index; Injections; Radiographic Image Enhancement; 03 medical and health sciences; 0302 clinical medicine; Fluorodeoxyglucose F18; Humans; Female; Algorithms; Aged

The PET image quality of overweight patients and who receive low injected doses deteriorates because increases in statistical noise. purpose this study was to investigate the benefits point-spread function (PSF) time-of-flight (TOF) for PET/CT such patients.The images were reconstructed using baseline ordered-subsets expectation-maximization algorithm (OSEM), OSEM + PSF, TOF, PSF TOF. In phantom study, we used a National Electrical Manufacturers Association body with different radioactivity concentrations analyzed coefficient variance background (CVphantom). clinical retrospectively studied 39 underwent F-FDG PET/CT. classified into groups based on mass index dose. Image evaluated CV liver (CVliver).In TOF improved CVphantom, especially low-activity models. Among all reconstructions, best CVphantom obtained CVliver low-dose group comparable that high-dose conventional OSEM.Point-spread received lower Therefore, use is suggested maintain without extending scanning times. It greatly beneficial obtain sufficient larger patients, delivery institutions where injection dose cannot be easily increased.