The Role of 11C-Choline PET Imaging in the Early Detection of Recurrence in Surgically Treated Prostate Cancer Patients With Very Low PSA Level <0.5 ng/mL

• DOI: 10.1097/rlu.0b013e31829af913
• Publication Date: 2013-06-22T14:34:38Z
• Authors: Marcelo Mamede; Francesco Ceci; Paolo Castellucci; Riccardo Schiavina; Chiara Fuccio; Cristina Nanni; Eugenio Brunocilla; Lorenzo Fantini; Stefano Costa; Alice Ferretti; Patrick M. Colletti; Domenico Rubello; Stefano Fanti
• Keywords: Choline; Biochemical recurrence; PET-CT; Transrectal ultrasonography

This study aims to evaluate the role of (11)C-choline PET/CT in patients with biochemical relapse after radical prostatectomy (RP) showing prostate-specific antigen (PSA) values lower than 0.5 ng/mL.We performed 71 consecutive previously treated RP PSA ng/mL. (11)C-Choline was following standard procedure. PET/CT-positive findings were validated by transrectal ultrasonography + biopsy, repeated PET/CT, other conventional imaging modality, and histology.(11)C-Choline true positive 15/71 (21.1%). uptake observed pelvic lymph nodes (7/71; 9.9%), prostatic bed bone (1/71; 1.4%). Mean PSA, doubling time (PSAdt), velocity (PSAvel) ± SD 0.37 0.1 ng/mL, 3.4 2.1 months, 0.05 ng/mL/yr, respectively. false negative 2 1 patient. Among all variables, only PSAdt ongoing hormonal treatment statistically significant prediction a at multivariate analysis.(11)C-Choline could be used early failure even if are very low, preferentially resistant fast kinetics. An detection site lead personalized tailored treatment.