Immunohistochemical Comparison of the Expression of p53 and MDM2 Proteins in Ameloblastomas and Keratocystic Odontogenic Tumors

• DOI: 10.1097/scs.0b013e31823188e9
• Publication Date: 2011-10-04T20:02:28Z
• Authors: Noorieh Sharifi-S...; Hamed Zartab; Shahab Babakoohi; Nasrollah Saghrav...; Shokoofeh Jamshidi; Habibollah Esmaili; Nooshin Mohtasham; Maryam Zamanzadeh; Hamid Abbaszadeh-...
• Keywords: Adenomatoid odontogenic tumor

Objective: Ameloblastoma and keratocystic odontogenic tumor (KOT) is characterized by a benign but locally invasive behavior with high risk of recurrence. MDM2 (murine double minute 2), an amplifier cell proliferation, p53, suppressor gene, are overexpressed in some lesions. The aim this study was to compare the expression p53 ameloblastoma KOT as 2 lesions similar biologic behavior, immunohistochemistry. Methods: expressions proteins were determined 39 ameloblastomas (15 follicular types, 15 plexiform 9 unicystic types) KOTs. Results: P53 protein expressed 100% KOTs 77.8% ameloblastomas, detected 74.8% 80% There no statistical difference between different subtypes also when compared them (P > 0.05). significant immunohistochemical reactivity among < positively correlated. Conclusions: Overexpression associated pathogenesis oncogenesis KOT. these markers can contribute