PROTECTIVE EFFECTS OF HYDROGEN GAS ON MURINE POLYMICROBIAL SEPSIS VIA REDUCING OXIDATIVE STRESS AND HMGB1 RELEASE

• DOI: 10.1097/shk.0b013e3181cdc4ae
• Publication Date: 2010-03-23T06:48:27Z
• Authors: Keliang Xie; Yonghao Yu; Yuping Pei; Lichao Hou; Shaoyang Chen; Lize Xiong; Guolin Wang
• Keywords: HMGB1

Despite recent advances in antibiotic therapy and intensive care, sepsis is still considered to be the most common cause of death care units. Excessive production reactive oxygen species plays an important role pathogenesis sepsis. Recently, it has been suggested that molecular hydrogen (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radicals (*OH, cytotoxic species) effectively protects against organ damage induced I/R. Therefore, we hypothesized H2 treatment had beneficial effect on In present study, found inhalation starting at 1 6 h after cecal ligation puncture (CLP) or sham operation significantly improved survival rate septic mice with moderate severe CLP concentration- time-dependent manner. Furthermore, showed significant multiple characterized increases lung myeloperoxidase activity, wet-to-dry weight ratio, protein concentration bronchoalveolar lavage, serum biochemical parameters, histopathologic scores 24 operation, which was attenuated 2% treatment. addition, effects sepsis-associated were associated decreased levels oxidative product, increased activities enzymes, reduced high-mobility group box tissue. Thus, may effective strategy for patients