Influence of Surgical Margins on Outcome in Patients With Intrahepatic Cholangiocarcinoma

• DOI: 10.1097/sla.0b013e318236c21d
• Publication Date: 2011-10-29T12:56:55Z
• Authors: Olivier Farges; David Fuks; Emmanuel Boleslawski; Yves-Patrice Le T...; Denis Castaing; Alexis Laurent; Christian Ducerf; Michel Rivoire; Philippe Bachellier; Laurence Chiche; Gennaro Nuzzo; Jean Marc Regimbeau
• Keywords: Intrahepatic Cholangiocarcinoma; Resection margin; Surgical margin

Define the optimal surgical margin in patients undergoing surgery for intrahepatic cholangiocarcinoma (IHCC).Surgery is most effective treatment IHCC. However, influence of R1 resection on outcome controversial and that width has not been evaluated.We studied 212 curative mass-forming-type The respective influences survival status (R0 vs R1), width, pTNM stage, latter's components were evaluated.Incidence was 24%. Overall, an independent predictor [odds ratio (OR) 1.2 (0.7-2.1)] contrast to stage [OR 2.10 (1.2-3.5)]. In 78 pN+ patients, similar after R0 resections (median: 18 13 months, respectively, P = 0.1). 134 pN0 poor 9.6 (4.5-20.4)], as presence satellite nodules 1.9 (1.1-3.2)]. 116 with resections, median correlated (≤1 mm: 15 months; 2-4 36 5-9 57 month; ≥10 64 month, < 0.001) a >5 mm 2.22 (1.59-3.09)].Patients IHCC are at high risk resections. strongest least 5 should be created. benefits general very low.