Long-Term Survival, Nutritional Autonomy, and Quality of Life After Intestinal and Multivisceral Transplantation

• DOI: 10.1097/sla.0b013e318265f310
• Publication Date: 2012-08-07T07:43:38Z
• Authors: Kareem M. Abu-Elmagd; Beverly Kosmach-Park; Guilherme Costa; Mazen Zenati; Lillian Martin; Darlene A. Koritsky; Maureen Emerling; Noriko Murase; Geoffrey J. Bond; Kyle Soltys; Hiroshi Sogawa; John Lunz; Motaz Al Samman; Nico Shaefer; Rakesh Sindhi; George V. Mazariegos
• Keywords: Adult; Male; Adolescent; Graft Survival; Infant; Organ Transplantation; Middle Aged; Kidney Transplantation; Liver Transplantation; 3. Good health; Intestines; Eating; Intestinal Diseases; 03 medical and health sciences; Cross-Sectional Studies; Postoperative Complications; 0302 clinical medicine; Child, Preschool; Humans; Female; Prospective Studies; Child; Follow-Up Studies

In Brief Objective: To assess long-term survival, graft function, and health-related quality of life (QOL) after visceral transplantation. Background: Despite continual improvement in early the therapeutic efficacy transplantation has yet to be defined. Methods: A prospective cross-sectional study was performed on 227 allograft recipients who survived beyond 5-year milestone. Clinical data were used outcome including function survival predictors. The socioeconomic milestones QOL measures assessed by clinical evaluation, professional consultation, validated inventory. Results: Of 376 recipients, 5 years, with conditional 75% at 10 years 61% 15 years. With a mean follow-up ± 4 177 (92 adults, 85 children) are alive, 118 (67%) 18 or older. Nonfunctional social support noninclusion liver most significant risk factors. Nutritional autonomy achievable 160 (90%) survivors, current serum albumin level 3.7 0.5 gm/dL body mass index 25 6 kg/m2. coexistence development neuropsychiatric disorders, survivors reintegrated society self-sustained status. parallel, psychological, emotional, significantly (P < 0.05) improved Current morbidities potential impact global health included dysmotility (59%), hypertension (37%), osteoporosis (22%), diabetes (11%), higher incidence among adult recipients. Conclusions: new tactics further improve measures, achieved excellent nutritional good QOL. Three metrics procedure life. Early consideration for gut rehabilitation autologous bowel reconstructive transplant surgery is recommended, particularly pediatric population, reduce life-long disorders.